It is 1983, and Hinamizawa is under quarantine. A mysterious and deadly virus has been discovered within the small village, and its residents—such as teenager Keiichi Maebara and his friends Mion Sonozaki and Rena Ryuuguu—are left confused and frightened by the situation.

As the villagers begin to search for a way to stop the affliction from spreading, some make drastic plans, which leaves Keiichi and his friends looking for a way to escape the village. But when tensions reach an all-time high, some of his group may not make it out unscathed as they fight for their lives against enemies both seen and unseen.